ARP37729C-21 [Polyclonal Antibody]
Cleaved Drosophila Dcp-1 (Asp216) Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IF
Immunogen Range:   A synthetic peptide corresponding to amino-terminal residues adjacent to Asp216 of Drosophila Dcp-1 protein
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   37729(Drosophila)
Swiss Prot:   O02002
Synonyms:   /
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Cell death in the fruit fly Drosophila melanogaster is regulated by many of the same stimuli as mammalian cell death (1). The Drosophila genome contains seven caspase genes; three encode initiator caspases, and four encode effector caspases (reviewed in (2)). The Drosophila effector caspase, death caspase-1 (Dcp-1), is a critical executioner of apoptosis. It is involved in the proteolytic cleavage of many key proteins, such as the nuclear enzyme poly (ADP-ribose) polymerase (PARP). The activation of Dcp-1 requires proteolytic processing of its inactive zymogen into active p22 and p13 fragments (3). Comparison of the in vivo activity between DrICE and Dcp-1 has shown that DrICE is a more effective inducer of apoptosis than Dcp-1, which instead plays a role in determining the rate of cell death (4).
Caculated MW:   22 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
IF 1:100
Reacitivity:   D. melanogaster
For research use only. Not intended for diagnostic or therapeutic use!
Additional information