ARM4088P-21 [Monoclonal Antibody]
Phospho-SMAD3-Ser423/425 Rabbit Monoclonal Antibody
www.yhsbio.com
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
Species:   Rabbit
Applications:   WB IP ChIP
Immunogen Range:   A synthetic phosphopeptide corresponding to residues surrounding Ser423/425 of Smad3
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   4088
Swiss Prot:   P84022
Synonyms:   HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Smad proteins belong to a group of intracellular signal transducers and downstream effectors of TGF-β/BMP Signaling. The family consists of nine members that are highly conserved in the N- and C-terminal regions. Smad3 is a key component in intracellular signaling of transforming growth factor beta (TGF-β), an inhibitor for tumor cell proliferation. Smad3 is activated by activin/TGF-β receptors, which form a heteromeric complex with Smad4, translocating to the nucleus and regulating the expression of TGF- β target genes. Interaction of Smad3 with Akt, can initiate TGF- β induced apoptosis and cell cycle arrest. Smad3 expression may be critical in tumor suppression in early stages of gastric carcinogenesis.
Caculated MW:   52 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
ChIP 1:100
Dot 1:100
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information