ARP43514C-21 [Polyclonal Antibody]
Cleaved Drosophila ICE (Asp230) Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB
Immunogen Range:   A synthetic peptide corresponding to amino-terminal residues adjacent to Asp230 of Drosophila ICE protein
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   43514(Drosophila)
Swiss Prot:   O01382
Synonyms:   /
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Cell death in the fruit fly Drosophila melanogaster is regulated by many of the same stimuli as mammalian cell death (1). The Drosophila genome contains seven caspase genes; three encode initiator caspases and four encode effector caspases (reviewed in 2). drICE is a cysteine protease that cleaves baculovirus p35 and lamin DmO in vitro and acts downstream of rpr (3). drICE is proteolytically processed during apoptosis into active p21 and p12 subunits. Comparison of the in vivo activity between drICE and Dcp-1 has shown that drICE is a more effective inducer of apoptosis than Dcp-1, which plays a role in determining the rate of cell death (4).
Caculated MW:   21 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
Reacitivity:   D. melanogaster
For research use only. Not intended for diagnostic or therapeutic use!
Additional information