MRM12370C-22S
[Monoclonal Antibody]
Cleaved CASP8 (Asp387) Rabbit Monoclonal Antibody (Mouse Specific)
www.yhsbio.com
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support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
| Species: | Rabbit |
| Applications: | WB |
| Immunogen Range: | A synthetic peptide corresponding to residues adjacent to the Asp387 cleavage site of rodent caspase-8 |
| Clonality: | Monoclonal Antibody |
| Isotype: | / |
| GENE ID: | 12370(Mouse) |
| Swiss Prot: | O89110 |
| Synonyms: | MACH, Mch5, FLICE, CASP-8 |
| Purification: | Affinity purification |
| Storage: | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Background: | Apoptosis induced through the CD95 receptor (Fas/APO-1) and tumor necrosis factor receptor 1 (TNFR1) activates caspase-8 and leads to the release of the caspase-8 active fragments, p18 and p10 (1-3). Activated caspase-8 cleaves and activates downstream effector caspases such as caspase-1, -3, -6, and -7. Caspase-3 ultimately elicits the morphological hallmarks of apoptosis, including DNA fragmentation and cell shrinkage. |
| Caculated MW: | 18, 43 kDa |
| Observed MW: | Refer to Figures |
| Applications: |
WB 1:1000 |
| Reacitivity: | Mouse |
For research use only. Not intended for diagnostic or therapeutic use!
Additional information