ARPF028P-21 [Polyclonal Antibody]
Phospho-GSK3A/B-Ser21/9 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC
Immunogen Range:   A synthetic phosphopeptide corresponding to the sequence of human GSK-3 alpha
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   2931/2932
Swiss Prot:   P49840/P49841
Synonyms:   /
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin (1). GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β (2,3). GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development (4). GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization (5).
Caculated MW:   46 kDa GSK-3beta. 51 kDa GSK-3alpha.
Observed MW:   Refer to Figures
Applications:   WB 1:1000
IHC 1:50
Reacitivity:   Human, Monkey, Mouse, Rat, Zebrafish
For research use only. Not intended for diagnostic or therapeutic use!
Additional information