ARMF028P-21S
[Monoclonal Antibody]
Phospho-GSK3A/B-Ser21/9 Rabbit Monoclonal Antibody (GSK3A Preferred)
www.yhsbio.com
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support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
| Species: | Rabbit |
| Applications: | WB IP |
| Immunogen Range: | A synthetic phosphopeptide corresponding to residues around Ser21 of human GSK-3α |
| Clonality: | Monoclonal Antibody |
| Isotype: | IgG |
| GENE ID: | 2931/2932 |
| Swiss Prot: | P49840/P49841 |
| Synonyms: | / |
| Purification: | Affinity purification |
| Storage: | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Background: | Glycogen synthase kinase-3 (GSK-3) was initially identified as an enzyme that regulates glycogen synthesis in response to insulin (1). GSK-3 is a ubiquitously expressed serine/threonine protein kinase that phosphorylates and inactivates glycogen synthase. GSK-3 is a critical downstream element of the PI3K/Akt cell survival pathway whose activity can be inhibited by Akt-mediated phosphorylation at Ser21 of GSK-3α and Ser9 of GSK-3β (2,3). GSK-3 has been implicated in the regulation of cell fate in Dictyostelium and is a component of the Wnt signaling pathway required for Drosophila, Xenopus, and mammalian development (4). GSK-3 has been shown to regulate cyclin D1 proteolysis and subcellular localization (5). |
| Caculated MW: | 51, 46 kDa |
| Observed MW: | Refer to Figures |
| Applications: |
WB 1:1000 |
| Reacitivity: | Human, Monkey, Mouse, Rat |
For research use only. Not intended for diagnostic or therapeutic use!
Additional information