ARM5925P-23C [Monoclonal Antibody]
Phospho-RB1-Ser807/811 Rabbit Monoclonal Antibody (Alexa Fluor(R) 594 Conjugate)
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Species:   Rabbit
Applications:   IF FC
Immunogen Range:   A synthetic phosphopeptide corresponding to residues surrounding Ser807/811 of human Rb protein
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   5925
Swiss Prot:   P06400
Synonyms:   RB, pRb, OSRC, pp110, p105-Rb
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Caculated MW:   110 kDa
Observed MW:   Refer to Figures
Applications:   IF 1:50
FC 1:50
Reacitivity:   Human, Monkey, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information