Species: | Rabbit |
Applications: | WB IF FC |
Immunogen Range: | A synthetic phosphopeptide corresponding to residues surrounding Ser167 and Ser170 of human MARCKS protein |
Clonality: | Monoclonal Antibody |
Isotype: | IgG |
GENE ID: | 4082 |
Swiss Prot: | P29966 |
Synonyms: | 80K-L, FLJ14368, FLJ90045, MACS, PKCSL, PRKCSL |
Purification: | Affinity purification |
Storage: | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
Background: | The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. |
Caculated MW: | 75 kDa rodent, 80 kDa human |
Observed MW: | Refer to Figures |
Applications: |
WB 1:1000 IF 1:100 FC 1:200 |
Reacitivity: | Human, Mouse, Rat |