ARM3059P-21 [Monoclonal Antibody]
Phospho-HCLS1-Tyr397 Rabbit Monoclonal Antibody
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Species:   Rabbit
Applications:   WB IF FC
Immunogen Range:   A synthetic phosphopeptide corresponding to residues surrounding Tyr405 of mouse HS1 protein This site corresponds to Tyr397 of human HS1 protein
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   3059
Swiss Prot:   P14317
Synonyms:   CTTNL, HS1
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   HS1 (HCLS1, LckBP1, p75) is a protein kinase substrate that is expressed only in tissues and cells of hematopoietic origin (1,2). HS1 contains four cortactin repeats and a single SH3 domain (2). This intracellular protein is phosphorylated following immune receptor activation, which promotes recruitment of HS1 to the immune synapse (3-5). Phosphorylation of HS1 is required to regulate actin dynamics and provide docking sites for many other signaling molecules, such as Vav1 and PLCγ1 (6). HS1 also plays an important role in platelet activation (7).HS1 is rapidly phosphorylated at Tyr397 by Syk and/or Lyn kinases following immune receptor stimulation and thrombin-mediated platelet stimulation. This phosphorylation is an important step in cytoskeletal rearrangement and signaling complex formation (6-10).
Caculated MW:   80 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
IF 1:50
FC 1:200
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information