ARM5335P-21 [Monoclonal Antibody]
Phospho-PLCG1-Ser1248 Rabbit Monoclonal Antibody
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Species:   Rabbit
Applications:   WB IHC IP IF FC
Immunogen Range:   A synthetic peptide corresponding to residues surrounding Ser1248 of human PLCγ1 protein
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   5335
Swiss Prot:   P19174
Synonyms:   PLC1, NCKAP3, PLC-II, PLC148, PLCgamma1
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor-mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate to the Golgi, where it activates Ras. Also, this protein has been shown to be a major substrate for heparin-binding growth factor 1 (acidic fibroblast growth factor)-activated tyrosine kinase. Two transcript variants encoding different isoforms have been found for this gene.
Caculated MW:   150 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
IHC 1:200
IF 1:100
FC 1:200
Reacitivity:   Human, Monkey, Mouse
For research use only. Not intended for diagnostic or therapeutic use!
Additional information