ARP5350P-21 [Polyclonal Antibody]
Phospho-PLN-Ser16/Thr17 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB
Immunogen Range:   A synthetic phosphopeptide corresponding to residues surrounding Ser16/Thr17 of human phospholamban protein
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   5350
Swiss Prot:   P26678
Synonyms:   CMD1P, PLB
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure. [provided by RefSeq
Caculated MW:   6 kDa (monomer); 12 kDa, 24 kDa (oligomers)
Observed MW:   Refer to Figures
Applications:   WB 1:1000
Reacitivity:   Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information