ARM51176P-21C [Monoclonal Antibody]
LEF1 Rabbit Monoclonal Antibody (Alexa Fluor(R) 488 Conjugate)
www.yhsbio.com
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
Species:   Rabbit
Applications:   FC
Immunogen Range:   A synthetic peptide corresponding to residues surrounding Pro82 of human LEF1 protein
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   51176
Swiss Prot:   Q9UJU2
Synonyms:   KFZp586H0919, TCF1ALPHA
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Lymphoid enhancer-binding factor 1(LEF1) belongs to a family of regulatory protein share homology with high mobility group protein-1, and it's a nuclear protein exprssed in pre-B and T cells. LEF1 has a role in the Wnt signaling pathway and hair cell differentiation and follicle morphogenesis. Together with CTNNB1 and EP300, LEF1 activates transcription of target genes. Isoform 5 transcriptionally activates the fibronectin promoter, binds to and represses transcription from the E-cadherin promoter in a CTNNB1-independent manner, and is involved in reducing cellular aggregation and increasing cell migration of pancreatic cancer cells. Isoform 1 transcriptionally activates MYC and CCND1 expression and enhances proliferation of pancreatic tumor cells
Caculated MW:   37 kDa
Observed MW:   Refer to Figures
Applications:   FC 1:50
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information