ARM5034P-24C [Monoclonal Antibody]
P4HB Rabbit Monoclonal Antibody (Alexa Fluor(R) 647 Conjugate)
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Species:   Rabbit
Applications:   IF
Immunogen Range:   /
Clonality:   Monoclonal Antibody
Isotype:   /
GENE ID:   5034
Swiss Prot:   P07237
Synonyms:   P4HB, DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHB
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   During their synthesis, secretory proteins translocate into the endoplasmic reticulum (ER) where they are post-translationally modified and properly folded. To reach their native conformation, many secretory proteins require the formation of intra- or inter-molecular disulfide bonds (1). This process is called oxidative protein folding. Protein disulfide isomerase (PDI) catalyzes the formation and isomerization of these disulfide bonds (2). Studies on mechanisms of oxidative folding suggest that molecular oxygen oxidizes the ER-protein Ero1, which in turn oxidizes PDI through disulfide exchange (3). This event is then followed by PDI-catalyzed disulfide bond formation in folding proteins (3).
Caculated MW:   57 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   /
For research use only. Not intended for diagnostic or therapeutic use!
Additional information