ARM840C-21 [Monoclonal Antibody]
Cleaved CASP7 (Asp198) Rabbit Monoclonal Antibody
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Species:   Rabbit
Applications:   WB IF FC
Immunogen Range:   A synthetic peptide corresponding to residues surrounding Asp198 of human caspase-7 protein
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   840
Swiss Prot:   P55210
Synonyms:   CMH-1, ICE-LAP3, MCH3, CASP7, Caspase-7
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Caspase-7 (CMH-1, Mch3, ICE-LAP3) has been identified as a major contributor to the execution of apoptosis (1-4). Caspase-7, like caspase-3, is an effector caspase that is responsible for cleaving downstream substrates such as (ADP-ribose) polymerase and PARP (1,3). During apoptosis, caspase-7 is activated through proteolytic processsing by upstream caspases at Asp23, Asp198, and Asp206 to produce the mature subunits (1,3). Similar to caspase-2 and -3, caspase-7 preferentially cleaves substrates following the recognition sequence DEVD (5).
Caculated MW:   18 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
IF 1:400
FC 1:1600
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information