ARP3082-31 [Polyclonal Antibody]
HGF Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC ICC
Immunogen Range:   A recombinant protein of human HGF
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   3082
Swiss Prot:   P14210
Synonyms:   SF, HGFB, HPTA, F-TCF, DFNB39
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
Caculated MW:   83 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:100-1:400
IHC 1:50-1:200
ICC 1:100-1:500
Reacitivity:   Human, Mouse, Rabbit, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information