ARMM012P-22 [Monoclonal Antibody]
Phospho-Ser/Thr ATM/ATR Substrate (S*/T*QG) Rabbit Monoclonal Antibody
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Species:   Rabbit
Applications:   WB IP
Immunogen Range:   A synthetic peptide containing the S*/T*QG motif The antibody is formulated from two rabbit monoclones in order to cover a broad range of reactivity
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   /
Swiss Prot:   /
Synonyms:   /
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Ataxia telangiectasia mutated kinase (ATM) and ataxia telangiectasia and Rad3-related kinase (ATR) are related kinases that regulate cell cycle checkpoints and DNA repair (1). The identified substrates for ATM are p53, p95/NBS1, MDM2, Chk2, BRCA1, CtIP, 4E-BP1, and Chk1 (1,2) The essential requirement for the substrates of ATM/ATR is S*/T*Q. Hydrophobic amino acids at positions -3 and -1, and negatively charged amino acids at position +1 are positive determinants for substrate recognition by these kinases. Positively charged residues surrounding the S*/T*Q are negative determinants for substrate phosphorylation (3). The complex phenotype of AT cells suggests that it likely has additional substrates (3).
Caculated MW:   /
Observed MW:   Refer to Figures
Applications:   WB 1:1000
Reacitivity:   All
For research use only. Not intended for diagnostic or therapeutic use!
Additional information