ARM52231-21 [Monoclonal Antibody]
ANKZF1 Rabbit Monoclonal Antibody
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Species:   Rabbit
Applications:   WB
Immunogen Range:   A synthetic peptide corresponding to residues surrounding Gly332 of mouse VMS1 protein
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   52231(Mouse)
Swiss Prot:   Q80UU1
Synonyms:   /
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Mitochondria are membrane-bound subcellular organelles critical to many functions in eukaryotic cells (1). Several mechanisms have been found to play a role in mitochondria quality control (2). A recent study identified mitochondria-associated protein degradation as one such mechanism (1,2). The study showed that VMS1 (VCP/Cdc48-associated mitochondrial stress-responsive) interacts with VCP/Cdc48 and Npl4, two components in the endoplasmic reticulum-associated protein degradation pathway, and mediates the degradation of damaged mitochondrial proteins under stress conditions (1). Defective VMS1 compromises mitochondrial functions and cell viability (1).
Caculated MW:   100 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
Reacitivity:   Mouse
For research use only. Not intended for diagnostic or therapeutic use!
Additional information