ARM203068-27C [Monoclonal Antibody]
TUBB Rabbit Monoclonal Antibody (PE Conjugate)
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Species:   Rabbit
Applications:   FC
Immunogen Range:   A synthetic peptide corresponding to the amino terminus of human β-tubulin protein
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   203068
Swiss Prot:   P07437
Synonyms:   M40, MGC117247, MGC16435, OK/SW-cl.56, TUBB1, TUBB5
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   TMP21, a type I transmembrane protein, is a member of the p24 cargo protein family, which is highly enriched in the ER, the Golgi and coat protein (COP) I and II transport vesicles (1,2). TMP21 is involved in protein transport and vesicular targeting. In particular, TMP21 influences APP trafficking by stabilizing nascent APP. The absence of TMP21 leads to enhanced maturation and cell surface accumulation of APP (3). In addition, TMP21 is a non-essential component of the γ-secretase complex with the potential to modulate γ-secretase mediated cleavage and Aβ production without having an effect on ε-secretase activity (4).
Caculated MW:   55 kDa
Observed MW:   Refer to Figures
Applications:   FC 1:50
Reacitivity:   Bovine, Human, Monkey, Mouse, Rat, Zebrafish, (Chiken)
For research use only. Not intended for diagnostic or therapeutic use!
Additional information