ARM6446P-21 [Monoclonal Antibody]
Phospho-SGK1-Ser78 Rabbit Monoclonal Antibody
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Species:   Rabbit
Applications:   WB IP
Immunogen Range:   A synthetic phosphopeptide corresponding to residues surrounding Ser78 of human SGK1 protein
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   6446
Swiss Prot:   O00141
Synonyms:   SGK, SGK1
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Serum and glucocorticoid-inducible kinase (SGK) is a serine/threonine kinase closely related to Akt (1). SGK is rapidly induced in response to a variety of stimuli, including serum, glucocorticoid, follicle stimulating hormone, osmotic shock, and mineralocorticoids. SGK activation can be accomplished via HGF PI3K-dependent pathways and by integrin-mediated PI3K-independent pathways (2,3). Induction and activation of SGK has been implicated in activating the modulation of anti-apoptotic and cell cycle regulation (4-6). SGK also plays an important role in activating certain potassium, sodium, and chloride channels, suggesting its involvement in the regulation of processes such as cell survival, neuronal excitability, and renal sodium excretion (2). SGK is negatively regulated by ubiquitination and proteasome degradation (7).The MAP kinase family member BMK1 interacts with and activates SGK by phosphorylation at serine 78 (6).
Caculated MW:   54 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information