ARMF058-21 [Monoclonal Antibody]
RAB11A/B Rabbit Monoclonal Antibody
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Species:   Rabbit
Applications:   WB IP IF
Immunogen Range:   A synthetic peptide corresponding to residues near the amino terminus of human Rab11 protein
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   8766/9230
Swiss Prot:   P62491/Q15907
Synonyms:   /
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Rab11a, Rab11b and Rab25 are members of the Rab11 family of small Ras-like GTPases. Rab11 (isoforms Rab11a and Rab11b) functions as a key regulator in the recycling of perinuclear, plasma membrane and Golgi compartment endosomes (1,2). Despite some overlap, distinct differences exist between Rab11a and Rab11b in both their cellular distribution and functional roles. Rab11a is ubiquitously expressed while Rab11b is found mainly in the heart and brain (3,4). Like other Rab proteins, Rab11 exerts its function via interactions with Rab11 family interacting proteins (FIPs). While there are three distinct classes of FIPs, all appear to share a conserved carboxy-terminal Rab-binding domain that allows Rab-FIP protein interaction. When bound together, these proteins are thought to regulate membrane-associated protein sorting (5,6).
Caculated MW:   25 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:2000
IF 1:100
Reacitivity:   Human, Monkey, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information