ARP3014P-21 [Polyclonal Antibody]
Phospho-H2AFX-Ser139/Tyr142 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IP IF FC
Immunogen Range:   A synthetic phosphopeptide corresponding to residues surrounding Ser139 and Tyr142 of human H2AX protein
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   3014
Swiss Prot:   P16104
Synonyms:   H2A.X, H2A/X, H2AX
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Histone H2A.X belongs to the histone H2A family, which is synthesized in G1 and S phase. It is involved in nucleosomal organization of chromatin together with other histone proteins, and is specially important for recombination between immunoglobulin switch regions. H2A.X becomes phosphorylated on serine 139 (to form gamma-H2AFX or H2AX139ph) in response to DNA double strand breaks (DSBs) generated by exogenous genotoxic agents and by stalled replication forks, which promotes DNA repair and maintains genomic stability.
Caculated MW:   15 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
IF 1:100
FC 1:200
Reacitivity:   Human, Monkey, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information