ARM253260-21C [Monoclonal Antibody]
RICTOR Rabbit Monoclonal Antibody (Sepharose Bead Conjugate)
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Species:   Rabbit
Applications:   IP
Immunogen Range:   A synthetic peptide corresponding to the sequence around Leu1121 of human rictor protein
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   253260
Swiss Prot:   Q6R327
Synonyms:   DKFZp686B11164, KIAA1999, MGC39830, mAVO3
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian TOR (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals (1). mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GβL and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, GβL, Sin1, and rictor (1). The mTOR-rictor complex phosphorylates Ser473 of Akt/PKB in vitro (2). This phosphorylation is essential for full Akt/PKB activation. Furthermore, an siRNA knockdown of rictor inhibits Ser473 phosphorylation in 3T3-L1 adipocytes (3). This complex has also been shown to phosphorylate the rapamycin-resistant mutants of S6K1, another effector of mTOR (4).
Caculated MW:   200 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   Human, Mouse
For research use only. Not intended for diagnostic or therapeutic use!
Additional information