ARM3791-21C [Monoclonal Antibody]
KDR Rabbit Monoclonal Antibody (Sepharose Bead Conjugate)
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Species:   Rabbit
Applications:   IP
Immunogen Range:   A recombinant protein containing the carboxy-terminal 150 amino acid residues of human VEGF receptor 2 protein
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   3791
Swiss Prot:   P35968
Synonyms:   FLK1, CD309, VEGFR, VEGFR2
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Vascular endothelial growth factor receptor 2 (VEGFR2, KDR, Flk-1) is a major receptor for VEGF-induced signaling in endothelial cells. Upon ligand binding, VEGFR2 undergoes autophosphorylation and becomes activated (1). Major autophosphorylation sites of VEGFR2 are located in the kinase insert domain (Tyr951/996) and in the tyrosine kinase catalytic domain (Tyr1054/1059) (2). Activation of the receptor leads to rapid recruitment of adaptor proteins, including Shc, GRB2, PI3 kinase, NCK, and the protein tyrosine phosphatases SHP-1 and SHP-2 (3). Phosphorylation at Tyr1212 provides a docking site for GRB2 binding and phospho-Tyr1175 binds the p85 subunit of PI3 kinase and PLCγ, as well as Shb (1,4,5). Signaling from VEGFR2 is necessary for the execution of VEGF-stimulated proliferation, chemotaxis and sprouting, as well as survival of cultured endothelial cells in vitro and angiogenesis in vivo (6-8).
Caculated MW:   210, 230 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   Human, Mouse
For research use only. Not intended for diagnostic or therapeutic use!
Additional information