ARM55920-21 [Monoclonal Antibody]
RCC2 Rabbit Monoclonal Antibody
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Species:   Rabbit
Applications:   WB IF
Immunogen Range:   A synthetic peptide corresponding to residues near the carboxy terminus of human RCC2 protein
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   55920
Swiss Prot:   Q9P258
Synonyms:   TD-60
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   RCC2/TD-60 is a member of the RCC1 (regulator of chromosome condensation 1) family of guanine nucleotide exchange factors. RCC2/TD-60 is associated with the chromosome passenger complex (CPC), which also consists of aurora B kinase, borealin, INCENP (inner centromere protein) and survivin. The CPC acts at various stages of mitosis, interacts with microtubules and is required for proper chromosome segregation and cytokinesis. Regulation of aurora B kinase is key in the regulation of the CPC (reviewed in 1,2). In late mitosis, RCC2/TD-60 is required for spindle assembly and recruitment of survivin and aurora B (3). RCC2/TD-60 is also required for aurora B activation in vitro and localization of the CPC to centromeres (4).
Caculated MW:   60 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
IF 1:100
Reacitivity:   Human, Monkey, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information