AMM1499-23C [Monoclonal Antibody]
CTNNB1 Mouse Monoclonal Antibody (Alexa Fluor(R) 647 Conjugate)
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Species:   Mouse
Applications:   IF FC
Immunogen Range:   A synthetic peptide corresponding to the carboxy terminus of human β-catenin protein
Clonality:   Monoclonal Antibody
Isotype:   IgG1
GENE ID:   1499
Swiss Prot:   P35222
Synonyms:   CTNNB, DKFZp686D02253, FLJ25606, FLJ37923, β-catenin
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   β-catenin is an adherens junction protein. Adherens junctions (AJs; also called the zonula adherens) are critical for the establishment and maintenance of epithelial layers, such as those lining organ surfaces. AJs mediate adhesion between cells, communicate a signal that neighboring cells are present, and anchor the actin cytoskeleton. In serving these roles, AJs regulate normal cell growth and behavior. At several stages of embryogenesis, wound healing, and tumor cell metastasis, cells form and leave epithelia. This process, which involves the disruption and reestablishment of epithelial cell-cell contacts, may be regulated by the disassembly and assembly of AJs. AJs may also function in the transmission of the 'contact inhibition' signal, which instructs cells to stop dividing once an epithelial sheet is complete.[supplied by OMIM
Caculated MW:   92 kDa
Observed MW:   Refer to Figures
Applications:   IF 1:200
FC 1:50
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information