ARM4914P-21 [Monoclonal Antibody]
Phospho-NTRK1-Tyr490/NTRK2-Tyr516 Rabbit Monoclonal Antibody
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Species:   Rabbit
Applications:   WB IP
Immunogen Range:   A synthetic phosphopeptide corresponding to residues surrounding Tyr490 of human TrkA
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   4914
Swiss Prot:   P04629
Synonyms:   DKFZp781I14186, MTC, TRK, TRK1, TRKA, p140-TrkA
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq
Caculated MW:   140 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
Reacitivity:   Human, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information