ARM6416P-21 [Monoclonal Antibody]
Phospho-MAP2K4-Ser257 Rabbit Monoclonal Antibody
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Species:   Rabbit
Applications:   WB FC
Immunogen Range:   A synthetic phosphopeptide corresponding to residues surrounding Ser257/Thr261 of human SEK1/MKK4
Clonality:   Monoclonal Antibody
Isotype:   /
GENE ID:   6416
Swiss Prot:   P45985
Synonyms:   JNKK, MEK4, MKK4, SEK1, SKK1, JNKK1, SERK1, MAPKK4, PRKMK4, SAPKK1, SAPKK-1
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   This gene encodes a member of the mitogen-activated protein kinase (MAPK) family. Members of this family act as an integration point for multiple biochemical signals and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. They form a three-tiered signaling module composed of MAPKKKs, MAPKKs, and MAPKs. This protein is phosphorylated at serine and threonine residues by MAPKKKs and subsequently phosphorylates downstream MAPK targets at threonine and tyrosine residues. A similar protein in mouse has been reported to play a role in liver organogenesis. A pseudogene of this gene is located on the long arm of chromosome X. Alternative splicing results in multiple transcript variants.
Caculated MW:   44 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
FC 1:400
Reacitivity:   Human, Monkey, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information