ARP47P-21 [Polyclonal Antibody]
Phospho-ACLY-Ser455 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IP
Immunogen Range:   A synthetic phosphopeptide corresponding to residues surrounding Ser455 of human ATP-citrate lyase
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   47
Swiss Prot:   P53396
Synonyms:   ACL, ATPCL, CLATP
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   ACLY(ATP-citrate synthase) is also named as ACL. It is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA. ACLY serves as not only a target in oxygenated cells for suppression of lipid synthesis and histone acetylation, but also as a susceptible target in hypoxic cells to restore inhibition of glycolysis. In nonsmall cell lung carcinoma and hepatocellular carcinoma ,ACLY is overexpressed compared with normal parenchyma suggesting that ACLY may represent a common target among highly malignant tumors(PMID:19795461). This protein has 2 isoforms produced by alternative splicing. This antibody is specific to ACLY.
Caculated MW:   125 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
Reacitivity:   Human, Mouse
For research use only. Not intended for diagnostic or therapeutic use!
Additional information