Species: | Rabbit |
Applications: | WB IHC ELISA IP IF |
Immunogen Range: | A synthesised phosphopeptide derived from human CASP9 around the phosphorylation site of Thr125 |
Clonality: | Polyclonal Antibody |
Isotype: | IgG |
GENE ID: | 842 |
Swiss Prot: | P55211 |
Synonyms: | APAF-3, APAF3, CASPASE-9c, ICE-LAP6, MCH6 |
Purification: | Affinity purification |
Storage: | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
Background: | This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspase APAF1; this step is thought to be one of the earliest in the caspase activation cascade. Alternative splicing results in two transcript variants which encode different isoforms. |
Caculated MW: | 35 kDa |
Observed MW: | Refer to Figures |
Applications: |
WB 1:100-1:500 IHC 1:100-1:500 IF 1:100-1:500 |
Reacitivity: | Human, Rat |