AMM17760-21 [Monoclonal Antibody]
MAP6 Mouse Monoclonal Antibody
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Species:   Mouse
Applications:   WB IF
Immunogen Range:   purified N-STOP from rat brain The antigen is encoded by exon 4 (Galiano et al, 2004)
Clonality:   Monoclonal Antibody
Isotype:   IgG1
GENE ID:   17760(Mouse)
Swiss Prot:   Q7TSJ2
Synonyms:   /
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Stable Tubule Only Polypeptide (STOP) is a microtubule-associated protein, and its microtubule-stabilizing activity is regulated by calmodulin (1-2). STOPs have several tissue- and developmental-specific isoforms that are encoded by a single gene. Neurons express N-STOP (exons 1-4) and E-STOP (exons 1-3), fibroblasts express F-STOP (exons 1-2), oligodendrocytes express O-STOP, and astrocytes A-STOP (3). STOPs are the major contributors stabilizing microtubules that resist depolymerization due to cold or depolymerizing drugs. STOP knock-out mice display impaired synaptic plasticity associated with severe behavioral disorders in contrast to the anticipated neuronal development and brain anatomy defects (4).
Caculated MW:   120 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
IF 1:200
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information