ORP66830-21S [Polyclonal Antibody]
NACC1 Rabbit Polyclonal Antibody (Rodent Preferred)
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Species:   Rabbit
Applications:   WB
Immunogen Range:   A synthetic peptide corresponding to the amino acid sequence surrounding Ala321 of human NAC1 protein
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   66830(Mouse)/171454(Rat)
Swiss Prot:   Q7TSZ8/O35260
Synonyms:   Nac1, Btbd14b, 2010001H03Rik, 4930511N13Rik
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   NAC1 or nuclear accumbens-1 is a nuclear factor that belongs to the POZ/BTB (Pox virus and zinc finger/bric-a-brac tramtrack broad complex) domain family. Also known as BTBD14B, it was originally identified in a unique neuronal forebrain structure responsible for reward motivation and addictive behaviors (1,2). NAC1 recruits HDAC3 and HDAC4 to transcriptionally repress gene expression in neuronal cells (3) and specifically co-represses other POZ/BTB proteins in the central nervous system (4). NAC1 is upregulated in several tumor types, including breast, renal cell, and hepatocellular carcinoma, as well as high grade ovarian serous carcinoma, where it has long been suspected as a chemoresistance gene (5,6). The chemoresistance mechanism reportedly occurs through NAC1 negative regulation of the GADD45 pathway (7). NAC1 has also been described as part of the extended transcriptional network in pluripotent cells that involves Oct-4, Sox2, Nanog, Sall1, KLF4 and Sall4 (8).
Caculated MW:   62 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
Reacitivity:   Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information