ARP6833-31 [Polyclonal Antibody]
ABCC8 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC ELISA IP IF FC
Immunogen Range:   A synthetic peptide derived from human ABCC8
Clonality:   Polyclonal Antibody
Isotype:   IgG
GENE ID:   6833
Swiss Prot:   Q09428
Synonyms:   HI, SUR, HHF1, MRP8, PHHI, SUR1, ABC36, HRINS, TNDM2, SUR1delta2
Purification:   Affinity purification
Storage:   Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles.
Background:   The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternatively spliced transcript variants have been found for this gene.
Caculated MW:   175 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:100-1:500
IHC 1:100-1:500
IF 1:100-1:500
FC 1:100-1:500
Reacitivity:   Human, Mouse, Rat, Dog, Pig, Horse, Guinea pig
For research use only. Not intended for diagnostic or therapeutic use!
Additional information