ARPF026-21 [Polyclonal Antibody]
GNA11/GNAQ/GNAZ Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IHC IP
Immunogen Range:   A synthetic peptide corresponding to residues of human guanine nucleotide-binding protein Gα (q) subunit
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   2767 2776 2781
Swiss Prot:   P29992 P50148 P19086
Synonyms:   /
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Heterotrimeric guanine nucleotide-binding proteins (G proteins) consist of α, β and γ subunits and mediate the effects of hormones, neurotransmitters, chemokines and sensory stimuli. To date, over 20 known Gα subunits have been classified into four families, Gα(s), Gα(i/o), Gα(q) and Gα(12), based on structural and functional similarities (1,2). Phosphorylation of Tyr356 of Gα(q)/Gα(11) is essential for activation of the G protein, since phenylalanine substitution for Tyr356 changes the interaction of Gα with receptors and abolishes ligand-induced IP3 formation (3).
Caculated MW:   39, 41 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
IHC 1:100
Reacitivity:   Bovine, Human, Monkey, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information