ARM2775-21S [Monoclonal Antibody]
GNAO1 Rabbit Monoclonal Antibody (IP Preferred)
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Species:   Rabbit
Applications:   IP
Immunogen Range:   A synthetic peptide corresponding to residues surrounding Arg15 of human Gα(o)
Clonality:   Monoclonal Antibody
Isotype:   /
GENE ID:   2775
Swiss Prot:   P09471
Synonyms:   GNAO, EIEE17, G-ALPHA-o
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Heterotrimeric guanine nucleotide-binding proteins (G proteins) consist of α, β and γ subunits and mediate the effects of hormones, neurotransmitters, chemokines and sensory stimuli. To date, over 20 known Gα subunits have been classified into four families, Gα(s), Gα(i/o), Gα(q) and Gα(12), based on structural and functional similarities (1,2). Phosphorylation of Tyr356 of Gα(q)/Gα(11) is essential for activation of the G protein, since phenylalanine substitution for Tyr356 changes the interaction of Gα with receptors and abolishes ligand-induced IP3 formation (3).Gα(o) is the most abundant G protein in the brain and couples to serotonin, dopamine, GABA (B), opioid, glutamate and cholinergic receptors (4). Gα(o) -/- mice have neurological defects such as tremors, seizures and poor motor coordination (5).
Caculated MW:   40 kDa
Observed MW:   Refer to Figures
Applications:  
Reacitivity:   Mouse
For research use only. Not intended for diagnostic or therapeutic use!
Additional information