ORM15163-21S [Monoclonal Antibody]
HCLS1 Rabbit Monoclonal Antibody (Rodent Specific)
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Species:   Rabbit
Applications:   WB IHC IP FC
Immunogen Range:   A synthetic peptide corresponding to residues surrounding Leu310 of mouse HS1
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   15163(Mouse)/288077(Rat)
Swiss Prot:   P49710
Synonyms:   HS1, AW213261
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   HS1 (HCLS1, LckBP1, p75) is a protein kinase substrate that is expressed only in tissues and cells of hematopoietic origin (1,2). HS1 contains four cortactin repeats and a single SH3 domain (2). This intracellular protein is phosphorylated following immune receptor activation, which promotes recruitment of HS1 to the immune synapse (3-5). Phosphorylation of HS1 is required to regulate actin dynamics and provide docking sites for many other signaling molecules, such as Vav1 and PLCγ1 (6). HS1 also plays an important role in platelet activation (7).
Caculated MW:   80 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
IHC 1:100
FC 1:100
Reacitivity:   Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information