ARP2997P-21 [Polyclonal Antibody]
Phospho-GYS1-Ser641 Rabbit Polyclonal Antibody
www.yhsbio.com
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
Species:   Rabbit
Applications:   WB IHC IP
Immunogen Range:   A synthetic phosphopeptide corresponding to residues surrounding Ser641 of human liver glycogen synthase
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   2997
Swiss Prot:   P13807
Synonyms:   GSY, GYS
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Glycogen synthase (GS) is a key enzyme in the regulation of glycogen synthesis. There are two main isoforms of mammalian GS: the muscle and the liver isoform (1-2). Muscle GS is expressed in several tissues, and liver GS appears to be tissue specific (3). GS is regulated by multi-site phosphorylation and by the binding of allosteric ligands. Phosphorylation leads to inactivation of GS, but activity is restored by the binding of the allosteric activator glucose-6-phosphate, which induces its dephosphorylation and activation (4).Ser641 is one of the most important phosphorylation sites for the regulation of glycogen synthase (5).
Caculated MW:   85 to 90 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
IHC 1:50
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information