Species: | Rabbit |
Applications: | WB IHC ELISA IP IF |
Immunogen Range: | A synthetic peptide derived from human CYP7A1 |
Clonality: | Polyclonal Antibody |
Isotype: | IgG |
GENE ID: | 1581 |
Swiss Prot: | P22680 |
Synonyms: | CP7A, CYP7, CYPVII |
Purification: | Affinity purification |
Storage: | Store at -20°C or -80°C in PBS with 0.02% sodium azide and 50% glycerol. Avoid freeze/thaw cycles. |
Background: | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. |
Caculated MW: | 55 kDa |
Observed MW: | Refer to Figures |
Applications: |
WB 1:100-1:500 IHC 1:100-1:500 IF 1:100-1:500 |
Reacitivity: | Guinea pig, Human, Mouse, Pig, Rat, Rabbit |