ARM4869P-21 [Monoclonal Antibody]
Phospho-NPM1-Ser4 Rabbit Monoclonal Antibody
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Species:   Rabbit
Applications:   WB FC
Immunogen Range:   A synthetic phosphopeptide corresponding to residues around Ser4 of human NPM
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   4869
Swiss Prot:   P06748
Synonyms:   B23, NPM
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Nucleophosmin (NPM1,B23) is a putative ribosome assembly factor with a high affinity for peptides containing nuclear localization signals (NLSs). The transport of proteins across the nuclear envelope is a selective, multistep process involving several cytoplasmic factors. Proteins must be recognized as import substrates, dock at the nuclear pore complex and translocate across the nuclear envelope in an ATP-dependent fashion. Several cytosolic and nuclear proteins that are central to this process have been identified. The 38 kDa nuclear protein nucleophosmin is involved in ribosomal assembly and rRNA transport. It is an abundant protein that is highly phosphorylated by Cdc2 kinase during mitosis.
Caculated MW:   38 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
FC 1:100
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information