ARM26986AM-21
[Monoclonal Antibody]
Asymmetric-Methyl-PABPC1 (Arg455/Arg460) Rabbit Monoclonal Antibody
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support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
market@yhsbio.com
support@yhsbio.com
+86-21-54651191
Room 703,Building 6,333# Guiping
Rd.,Xuhui District,Shanghai,China
DATASHEET
| Species: | Rabbit |
| Applications: | WB IHC IP IF |
| Immunogen Range: | A synthetic peptide corresponding to the sequence of human PABP1 in which Arg455 and Arg460 are methylated |
| Clonality: | Monoclonal Antibody |
| Isotype: | IgG |
| GENE ID: | 26986 |
| Swiss Prot: | P11940 |
| Synonyms: | PAB1, PABP, PABP1, PABPC2, PABPL1 |
| Purification: | Affinity purification |
| Storage: | Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles. |
| Background: | The poly(A)-binding protein (PABP), which is found complexed to the 3-prime poly(A) tail of eukaryotic mRNA, is required for poly(A) shortening and translation initiation [PMID: 21989405]. Polyadenylate-binding protein 1 (PABPC1) is a cytoplasmic-nuclear shuttling protein important for protein translation initiation, and both RNA processing and stability. In the cytoplasm, PABPC1 binds to the 3' poly(A) tail of eukaryotic mRNAs through its RNA-recognition motifs (RRM) and interacts with the N-terminus of eIF4G, part of the eIF4F complex associated with the 5' cap structure [PMID:20009508, 17381337]. |
| Caculated MW: | 71 kDa |
| Observed MW: | Refer to Figures |
| Applications: |
WB 1:1000 IHC 1:1000 IF 1:400 |
| Reacitivity: | Human, Monkey, Mouse, Rat |
For research use only. Not intended for diagnostic or therapeutic use!
Additional information