ARM1956-22S [Monoclonal Antibody]
EGFR (L858R Mutant Specific) Rabbit Monoclonal Antibody
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Species:   Rabbit
Applications:   WB IHC IP IF FC
Immunogen Range:   A synthetic peptide corresponding to L858R mutant sequence of human EGF receptor
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   1956
Swiss Prot:   P00533
Synonyms:   ERBB, ERBB1, HER1, PIG61, mENA
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   The epidermal growth factor (EGF) receptor is a 170 kDa transmembrane tyrosine kinase that belongs to the HER/ErbB protein family. Research studies have shown that somatic mutations in the tyrosine kinase domain of EGF receptor (EGFR) are present in a subset of lung adenocarinomas that respond to EGFR inhibitors, such as gefinitib and erlotinib (1-3). Two types of mutations account for approximately 90% of mutated cases: a specific point mutation, L858R, that occurs in exon 21 and short in-frame deletions in exon 19 (4,5). The most frequent exon 19 deletion is E746-A750, accounting for 90% of lesions at this site, although some rare variants occur.
Caculated MW:   175 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
IHC 1:100
IF 1:400
FC 1:100
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information