ARMF051P-21 [Monoclonal Antibody]
Phospho-ZAP70-Tyr319/SYK-Tyr352 Rabbit Monoclonal Antibody
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Species:   Rabbit
Applications:   WB
Immunogen Range:   A synthetic phosphopeptide corresponding to residues surrounding Tyr319 of human Zap-70
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   6850/7535
Swiss Prot:   P43405/P43403
Synonyms:   /
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   The Syk family protein tyrosine kinase Zap-70 is expressed in T and NK cells and plays a critical role in mediating T cell activation in response to T cell receptor (TCR) engagement (1). Following TCR engagement, Zap-70 is rapidly phosphorylated on several tyrosine residues through autophosphorylation and transphosphorylation by the Src family tyrosine kinase Lck (2-6). Tyrosine phosphorylation correlates with increased Zap-70 kinase activity and downstream signaling events. Expression of Zap-70 is correlated with disease progression and survival in patients with chronic lymphocytic leukemia (7,8).
Caculated MW:   70, 72 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information