ARM7535-21C [Monoclonal Antibody]
ZAP70 Rabbit Monoclonal Antibody (Alexa Fluor(R) 647 Conjugate)
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Species:   Rabbit
Applications:   FC
Immunogen Range:   A synthetic peptide corresponding to residues surrounding the amino-terminus of human Zap-70
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   7535
Swiss Prot:   P43403
Synonyms:   FLJ17670, FLJ17679, SRK, STD, TZK, ZAP-70
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
Caculated MW:   70 kDa
Observed MW:   Refer to Figures
Applications:   FC 1:50
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information