ARP1981-21 [Polyclonal Antibody]
Phospho-EIF4G1-Ser1108 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IP IF
Immunogen Range:   A synthetic phosphopeptide corresponding to residues surrounding Ser1108 of human eIF4GI
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   1981
Swiss Prot:   Q04637
Synonyms:   DKFZp686A1451, EIF4F, EIF4G, p220
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   The initiation of translation is an important biological event and a variety of factors contribute to this process. Members of the eIF4 translation initiation factor family bind to the 5' m7GTP mRNA cap and unwind the mRNA secondary structure (1,2). The amino-terminal portion of eIF4G physically associates with eIF4E to stimulate the binding of eIF4E to the mRNA cap structure (3). eIF4G also interacts with eIF3 and eIF4A and serves as an adaptor molecule in the eIF4 complex (4). Moreover, eIF4G plays a role in internal ribosomal entry site (IRES)-mediated initiation of translation (5,6). The eIF4G family includes eIF4G1 (eIF4GI), eIF4G2 (p97, DAP5 or NAT1), and eIF4G3 (eIF4GII) (7). These factors share a homologous sequence that provides for interaction with initiation factors eIF3 and eIF4A. Both eIF4G1 and eIF4G3 are involved in cap-dependent translation, while eIF4G2 plays a role in IRES-mediated translation of some genes during cell stress (7,8).
Caculated MW:   220 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
IF 1:600
Reacitivity:   Hamster, Bovine, Human, Monkey, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information