ORP22166-21S [Polyclonal Antibody]
TXN1 Rabbit Polyclonal Antibody (Mouse/Rat Preferred)
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Species:   Rabbit
Applications:   WB
Immunogen Range:   A synthetic peptide corresponding to the sequence of mouse thioredoxin 1
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   22166(Mouse)/216484(Rat)
Swiss Prot:   P10639/P11232
Synonyms:   ADF, Txn, Trx1, AW550880
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Thioredoxin is a small redox protein found in many eukaryotes and prokaryotes. A pair of cysteines within a highly conserved, active site sequence can be oxidized to form a disulfide bond that is then reduced by thioredoxin reductase (1). Multiple forms of thioredoxin have been identified, including cytosolic thioredoxin 1 (TRX1) and mitochondrial thioredoxin 2 (TRX2). Thioredoxin participates in many cellular processes including redox signaling, response to oxidative stress and protein reduction (1). A potential role of thioredoxin in human disorders such as cancer, aging and heart disease is currently under investigation (2). Thioredoxin can play a key role in cancer progression, as it acts as a negative regulator of the proapoptotic kinase ASK1 (3). Changes in thioredoxin expression have been associated with meningococcal septic shock and acute lung injury (4,5).
Caculated MW:   12 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
Reacitivity:   Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information