ARP4000P-21 [Polyclonal Antibody]
Phospho-LMNA-Ser22 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IF
Immunogen Range:   A synthetic phosphopeptide corresponding to residues surrounding Ser22 of human lamin A/C protein
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   4000
Swiss Prot:   P02545
Synonyms:   CDCD1, CDDC, CMD1A, CMT2B1, EMD2, FPL, FPLD, HGPS, IDC, LDP1, LFP, LGMD1B, LMN1, LMNC, PRO1
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Through alternate splicing, this gene encodes three type A lamin isoforms. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
Caculated MW:   69, 78 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
IF 1:800
Reacitivity:   Human, Mouse, Rat
For research use only. Not intended for diagnostic or therapeutic use!
Additional information