HRP9140-21S [Polyclonal Antibody]
ATG12 Rabbit Polyclonal Antibody (Human Specific)
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Species:   Rabbit
Applications:   IP IF
Immunogen Range:   A synthetic peptide corresponding to residues near the amino terminus of human Atg12
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   9140
Swiss Prot:   O94817
Synonyms:   APG12, APG12L, FBR93, HAPG12
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of bulk cytoplasmic contents (1,2). Autophagy is generally activated by conditions of nutrient deprivation but has also been associated with a number of physiological processes including development, differentiation, neurodegeneration, infection, and cancer (3). The molecular machinery of autophagy was largely discovered in yeast and referred to as autophagy-related (Atg) genes. Formation of the autophagosome involves a ubiquitin-like conjugation system in which Atg12 is covalently bound to Atg5 and targeted to autophagosome vesicles (4-6). This conjugation reaction is mediated by the ubiquitin E1-like enzyme Atg7 and the E2-like enzyme Atg10 (7,8).
Caculated MW:   16, 55 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
IF 1:100
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information