ARM3059-21SC [Monoclonal Antibody]
HCLS1 Rabbit Monoclonal Antibody (Human Specific) (Alexa Fluor(R) 647 Conjugate)
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Species:   Rabbit
Applications:   IF FC
Immunogen Range:   A synthetic peptide corresponding to residues surrounding Pro310 of human HS1 protein
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   3059
Swiss Prot:   P14317
Synonyms:   CTTNL, HS1
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   HS1 (HCLS1, LckBP1, p75) is a protein kinase substrate that is expressed only in tissues and cells of hematopoietic origin (1,2). HS1 contains four cortactin repeats and a single SH3 domain (2). This intracellular protein is phosphorylated following immune receptor activation, which promotes recruitment of HS1 to the immune synapse (3-5). Phosphorylation of HS1 is required to regulate actin dynamics and provide docking sites for many other signaling molecules, such as Vav1 and PLCγ1 (6). HS1 also plays an important role in platelet activation (7).
Caculated MW:   80 kDa
Observed MW:   Refer to Figures
Applications:   IF 1:50
FC 1:50
Reacitivity:   Human
For research use only. Not intended for diagnostic or therapeutic use!
Additional information