ARP29086P-21 [Polyclonal Antibody]
Phospho-C19orf62-Ser29 Rabbit Polyclonal Antibody
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Species:   Rabbit
Applications:   WB IP
Immunogen Range:   A synthetic phosphopeptide corresponding to residues surrounding Ser29 of human MERIT40 protein
Clonality:   Polyclonal Antibody
Isotype:   /
GENE ID:   29086
Swiss Prot:   Q9NWV8
Synonyms:   C19orf62
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   The breast cancer susceptibility gene, BRCA1, codes for an E3 ubiquitin ligase that functions in the maintenance of genome stability through regulation of DNA damage response and DNA repair. BRCA1 forms at least three distinct complexes (BRCA1 A, B, and C) with other DNA repair proteins, and these interactions are vital for the regulation of BRCA1 function. The BRCA1-Rap80 complex (BRCA1 A complex), including Rap80, BRCC36, BRCC45, Abraxas, and MERIT40/NBA1, functions in G2/M phase checkpoint control (reviewed in 1,2).MERIT40/NBA1 localizes to sites of DNA damage and is required for the appropriate localization of BRCA1 in response to ionizing radiation, as well as maintenance of the BRCA1 A complex (3,4). Proteomics studies have identified Ser29 as a phosphorylated site on MERIT40/NBA1, and the significance of this phosphorylation is under investigation (5-9).
Caculated MW:   40 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
Reacitivity:   Human, Monkey
For research use only. Not intended for diagnostic or therapeutic use!
Additional information