ARM9815P-21 [Monoclonal Antibody]
Phospho-GIT2-Tyr392 Rabbit Monoclonal Antibody
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Species:   Rabbit
Applications:   WB
Immunogen Range:   A synthetic phosphopeptide corresponding to residues surrounding Tyr392 of human GIT2 protein
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   9815
Swiss Prot:   Q14161
Synonyms:   CAT-2, DKFZp686G01261, KIAA0148, MGC760
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.
Caculated MW:   85 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
Reacitivity:   Human, (Mouse, Rat)
For research use only. Not intended for diagnostic or therapeutic use!
Additional information