ARM3654-21C [Monoclonal Antibody]
IRAK1 Rabbit Monoclonal Antibody (Biotinylated)
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Species:   Rabbit
Applications:   W
Immunogen Range:   A synthetic peptide corresponding to residues near the carboxy terminus of mouse IRAK1 protein
Clonality:   Monoclonal Antibody
Isotype:   IgG
GENE ID:   3654
Swiss Prot:   P51617
Synonyms:   IRAK1, IRAK, pelle
Purification:   Affinity purification
Storage:   Store at -20°C in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Avoid freeze/thaw cycles.
Background:   Interleukin-1 (IL-1) receptor-associated kinase (IRAK) is a serine/threonine-specific kinase that can be coprecipitated in an IL-1-inducible manner with the IL-1 receptor (1). The mammalian family of IRAK molecules contains four members (IRAK1, IRAK2, IRAK3/IRAK-M, and IRAK4). The binding of IL-1 to IL-1 receptor type I (IL-1RI) initiates the formation of a complex that includes IL-1RI, AcP, MyD88, and IRAKs (2). IRAK undergoes autophosphorylation shortly after IL-1 stimulation. The subsequent events involve IRAK dissociation from the IL-1RI complex, its ubiquitination, and its association with two membrane-bound proteins: TAB2 and TRAF6. The resulting IRAK-TRAF6-TAB2 complex is then released into the cytoplasm where it activates protein kinase cascades, including TAK1, IKKs, and the stress-activated kinases (3).
Caculated MW:   78-105 kDa
Observed MW:   Refer to Figures
Applications:   WB 1:1000
Reacitivity:   Human, Monkey, Mouse
For research use only. Not intended for diagnostic or therapeutic use!
Additional information